ABSTRACT
Objectives: The present study was undertaken to study the incidence, etiological factor, and days of onset, clinical types and biochemical abnormalities in babies having neonatal seizures. Materials and Methods: This is a retrospective, observational hospital based study. Ninety neonates, who developed seizures before 28 days of life and admitted to neonatal intensive care unit and nursery with neonatal seizure, were evaluated for incidence, etiological factor, clinical types and biochemical abnormalities found in neonatal seizure. The variables were analysed using Chi- Square and student t- test. Results: The incidence of neonatal seizure was 10.3/ 1000 live births. The seizures were common in male babies. 65 (72.2%) neonates were born to multiparous women while 35 (38%) were born to primigravidas. In birth asphyxia (n= 40), the most common type of seizure observed was subtle seizure 20 (50%), followed by focal clonic 10 (25%) and multifocal clonic 5 (12.5%). Tonic type of seizure was observed in 3 (7.5%) and myoclonic in 2 (5%). Meningitis and septicaemia was the second most common cause of neonatal seizure observed in our study. Among metabolic abnormalities hypoglycaemia was found in 20 (22%) and hypocalcaemia in 10 (11%). Conclusion: The commonest cause of seizure was birth asphyxia presenting within 72 hours of life. Among infection septicaemia and meningitis was the most common cause leading to neonatal seizure. Among biochemical abnormalities the most common cause of seizure observed in our study was hypoglycaemia and hypocalcaemia. Subtle seizures were the commonest type of seizure observed in this study.
ABSTRACT
This survey was done in 682 out of 1672 children tested with Batch of Tuberculin used for Testing (PPD RT 23 with Tween 80) in Jan. 1997 with financial research grant of B.P. Koirala Institute of Health Sciences, Dharan. Dharan City is situated in Eastern Development Region (EDR) of Nepal where a high percentage of migrated population is residing with very high number of sputum positive cases. The majority of population are from high hills and mountain region where the Annual Risk of Infection (ARI) is less. This survey was done to know the epidemiological situation of Tuberculosis (TB) in Dharan. Tuberculin survey was done in Eastern Development Region (EDR) (1994) by National Tuberculosis Centre (NTC)/Japan International Cooperation Agency (JICA) in Saptari and Morang. The reported result of average Annual Risk of Infection (ARI) is 2.49% and 2.38% respectively. The mean age of surveyed population was 14.8 yrs. The Bacilli Calmette Guerin (BCG) coverage (scar rate) was 38.3% and BCG 4-8 age group 83.3% was highest and it gradually decreased to 37.5% in 12 + age group. The average 23 Tween-8-Batch of Tuberculin used for Testing (PPD) positive is 33.6% with 10 mm induration as cutoff line. Annual Risk of Infection (ARI) based on above was 2.7% in 9-11 age group and 1.31% in 12 + age group. This survey is suggestive of tuberculosis being highly prevalent in Dharan. The survey also showed average ARI to be 2.44% in Dharan in 10-15 yrs age group. The finding is suggestive of high ARI although the populations has migrated from hill and mountain. Previous report of average ARI in this area was 2.5% (Morang and Saptari). The survey result suggests that high priority, effective tuberculosis program is necessary and intensive control program can only give impact to control of tuberculosis in Dharan.